A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats

@article{McCoy2003ARO,
  title={A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats},
  author={John G McCoy and Chris Strawbridge and Kenneth D. McMurtrey and Victoria B Kane and Christopher Patrick Ward},
  journal={Brain Research Bulletin},
  year={2003},
  volume={60},
  pages={59-65}
}
The role of tetrahydropapaveroline (THP), a condensation product of a dopaldehyde with dopamine, in the regulation of alcohol consumption was investigated. In the first experiment, rats received intraventricular injections of either racemic THP hydrobromide (0.65 or 1.3 microg/microl), R-(+)-THP (0.66 or 1.4 microg/microl), or an equal volume of vehicle. The lower doses of both (+/-)-THP and (+)-THP significantly increased volitional alcohol intake. For the racemic compound, the increase was… CONTINUE READING

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