A re-evaluation of fumagillin selectivity towards endothelial cells.

  title={A re-evaluation of fumagillin selectivity towards endothelial cells.},
  author={Salvador Rodr{\'i}guez-Nieto and Miguel {\'A}ngel Medina and Ana Rodr{\'i}guez Quesada},
  journal={Anticancer research},
  volume={21 5},
We have re-evaluated the selectivity of fumagillin against endothelial cell proliferation and compared it to the reported selectivity of its potent analog TNP-470. We showed that fumagillin does not inhibit endothelial cell proliferation in a specific manner, but on the contrary it inhibits the proliferation of other cell types at the same range of concentrations. Furthermore, the IC50 values of fumagillin for endothelial cells are two orders of magnitude higher than those values reported for… CONTINUE READING


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