A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents


We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors. This triple agonist demonstrates… (More)
DOI: 10.1038/nm.3761


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