A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis

@article{Jameson1994ARD,
  title={A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis},
  author={B. A. Jameson and James M McDonnell and Joseph C. Marini and Robert Korngold},
  journal={Nature},
  year={1994},
  volume={368},
  pages={744-746}
}
EXPERIMENTAL allergic encephalomyelitis (EAE) is an acute inflammatory autoimmune disease of the central nervous system that can be elicited in rodents and is the major animal model for the study of multiple sclerosis (MS)1,2. The pathogenesis of both EAE and MS directly involves the CD4+ helper T-cell subset3–5. Anti-CD4 monoclonal antibodies inhibit the development of EAE in rodents6–9, and are currently being used in human clinical trials for MS. We report here that similar therapeutic… CONTINUE READING

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