A rational approach for assessing the hypothalamo-pituitary-adrenal axis.

@article{Stewart1988ARA,
  title={A rational approach for assessing the hypothalamo-pituitary-adrenal axis.},
  author={P. M. Stewart and John E. T. Corrie and Jonathan R Seckl and Christopher R. W. Edwards and Paul Lynch Padfield},
  journal={Lancet},
  year={1988},
  volume={1 8596},
  pages={1208-10}
}
In 70 paired insulin tolerance tests (ITTs) and short 'Synacthen' tests (SSTs), both of which have been advocated for assessment of the hypothalamo-pituitary-adrenal (HPA) axis, there were 51 passes on both tests, 9 failures on both, and 10 discrepant results (9 failures on the SST, 1 failure on the ITT). There was a close correlation between the maximum cortisol value achieved in the two tests. A survey of British endocrinologists showed that only 24% used the SST to assess the HPA axis. It is… CONTINUE READING

From This Paper

Topics from this paper.
50 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Similar Papers

Loading similar papers…