A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction.

@article{Zhang2018ARE,
  title={A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction.},
  author={Jing Zhang and Liang-Liang Wang and Mei-Feng Hou and Yao-Kun Xia and Wen-Hui He and A C Yan and Yun-Ping Weng and Lu-Peng Zeng and Jinghua Chen},
  journal={Biosensors & bioelectronics},
  year={2018},
  volume={102},
  pages={
          33-40
        }
}
Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes have attracted rapidly growing interest owing to their potential in diagnostic and prognostic applications. Here, we design a ratiometric electrochemical biosensor based on bipedal DNA walkers for the attomolar detection of exosomal miR-21. In the presence of miR-21, DNA walkers are activated to walk continuously along DNA tracks, resulting in conformational changes as well as considerable increases of the… CONTINUE READING