A rate theory model for Mg2+ block of ATP-dependent potassium channels of rat skeletal muscle.

Abstract

1. We have studied the block by intracellular Mg2+ (0.08-4mM) of ATP-dependent potassium channels (KATP channels) from rat skeletal muscle using inside-out excised sarcolemmal patches. The block is voltage dependent, is relieved by extracellular potassium and has rapid kinetics, allowing the use of amplitude distribution analysis to estimate on and off… (More)

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