A rat model of pancreatic ductal adenocarcinoma: targeting chemical carcinogens.

@article{Rivera1997ARM,
  title={A rat model of pancreatic ductal adenocarcinoma: targeting chemical carcinogens.},
  author={Johanna Rivera and Fiona Graeme-Cook and Jen Werner and Kaspar Z'graggen and Anil K Rustgi and David W. Rattner and Andrew Louis Warshaw and Carlos Fern{\'a}ndez-del Castillo},
  journal={Surgery},
  year={1997},
  volume={122 1},
  pages={82-90}
}
BACKGROUND Current experimental models of pancreatic cancer either fail to reproduce the ductal phenotype or cause simultaneous cancers in other organs also. To develop an animal of pancreatic cancer that accurately mimics the human condition, we restricted carcinogenic exposure to the pancreas and specifically targeted ductal epithelial cells. Three different carcinogens were either implanted directly into the pancreas or infused into the pancreatic duct, with or without near-total… CONTINUE READING
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