A rat model of neurolathyrism: repeated injection of L-β-ODAP induces the paraparesis of the hind legs

@article{KusamaEguchi2005ARM,
  title={A rat model of neurolathyrism: repeated injection of L-β-ODAP induces the paraparesis of the hind legs},
  author={Kuniko Kusama-Eguchi and Fumio Ikegami and Tadashi Kusama and Atsuhiro Suda and Yuki Ogawa and Kazuei Igarashi and Kazuko Watanabe},
  journal={Amino Acids},
  year={2005},
  volume={28},
  pages={139-143}
}
Neurolathyrisim is a motor neuron disease characterized by spastic paraparesis in the hind legs, and is caused by grass pea, Lathyrus sativus, which contains the excitotoxic amino acid, 3-N-oxalyl-L-2,3-diaminopropanoic acid (L-β-ODAP), an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamatergic receptor agonist. In an attempt to make a useful model of this disease, the CNS distribution and toxicity of L-β-ODAP was studied in rat neonates after parenteral administration… CONTINUE READING