A rat model of focal embolic cerebral ischemia

  title={A rat model of focal embolic cerebral ischemia},
  author={Rui Lan Zhang and Michael Chopp and Zheng Gang Zhang and Quan Jiang and James R. Ewing},
  journal={Brain Research},
We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cerebral blood flow (CBF) was measured by means of laser Doppler flowmetry (LDF) and perfusion weighted imaging (PWI) before and after embolization. The evolution of the lesion was… CONTINUE READING


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