A rat model for stable chronic obstructive pulmonary disease induced by cigarette smoke inhalation and repetitive bacterial infection.

@article{Li2012ARM,
  title={A rat model for stable chronic obstructive pulmonary disease induced by cigarette smoke inhalation and repetitive bacterial infection.},
  author={Ya Li and Su-Yun Li and Jian-sheng Li and Li Deng and Yange Tian and Su-li Jiang and Ying Wang and Yuanyuan Wang},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 10},
  pages={1752-60}
}
To develop a stable chronic obstructive pulmonary disease (COPD) model in rats. Sprague-Dawley rats were treated with cigarette-smoke inhalation (CSI) for 12 weeks, repetitive bacterial infection (RBI) for 8 weeks, or the combination of the two (CCR) for 12 weeks and followed up for the additional 20 weeks. Tidal volume (V(T)), peak expiratory flow (PEF) and 50% V(T) expiratory flow (EF(50)), histological changes in the lungs, and levels of the cytokines tumor necrosis factor (TNF… CONTINUE READING