A rat model for neural circuitry abnormalities in schizophrenia

  title={A rat model for neural circuitry abnormalities in schizophrenia},
  author={Sabina Berretta and Francine Mary Benes},
  journal={Nature Protocols},
Animal models for complex brain disorders, such as schizophrenia, are essential for the interpretation of postmortem findings. These models allow empirical testing of hypotheses regarding the role of genetic and environmental factors, the pathophysiological mechanisms and brain circuits that are responsible for specific neural abnormalities and their associated behavioral impairment, and the effectiveness of therapeutic treatments relative to these diseases. Recently, we developed a rodent… CONTINUE READING