A rat cell line derived from DMBA-induced mammary carcinoma.

  title={A rat cell line derived from DMBA-induced mammary carcinoma.},
  author={Louis Wing-Cheong Chow and Mary N B Cheung and Wings Tjing-yung Loo and Xin-yuan Guan},
  journal={Life sciences},
  volume={73 1},
A new cell line, designated UHKBR-01, was successfully established from a 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumour. DMBA was administered orally at a dose of 4 mg/ml per rat on the first day of the experiment and thereafter at weekly intervals of same dosage, until the rats have reached a weight of around 150-200 g. The tumours grew rapidly after the injection, and were transplanted into nude mice one the harvest size (2.5 x 2 x 1 mm(3)) was reached, it was transplanted… CONTINUE READING