A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.

@article{Zweifel2008ARA,
  title={A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.},
  author={Ben Scott Zweifel and Medora M. Hardy and Gary D. Anderson and Dawn R Dufield and Robert A. Pufahl and Jaime L. Masferrer},
  journal={European journal of pharmacology},
  year={2008},
  volume={584 1},
  pages={166-74}
}
The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflammatory diseases including asthma, atherosclerosis, rheumatoid arthritis, pain, cancer and liver fibrosis. Several classes of 5-LOX inhibitors have been identified, but only one drug, zileuton, a redox inhibitor of 5-LOX, has been approved for clinical use. To better evaluate the efficacy of 5-LOX inhibitors for pharmacological intervention, a rat model was modified to test the in vivo efficacy of 5-LOX inhibitors… CONTINUE READING
9 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…