A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.

@article{Buervenich2005ART,
  title={A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.},
  author={Silvia Buervenich and Andrea Carmine and Dagmar Galter and Haydeh Niazi Shahabi and Bo E A Johnels and Bj{\"o}rn Holmberg and Jarl Ahlberg and Hans Nissbrandt and Johanna Eerola and Olli Hellstr{\"o}m and Pentti J. Tienari and Tohru Matsuura and Tetsuo Ashizawa and U. W{\"u}llner and Thomas Klockgether and Alexander Zimprich and Thomas Gasser and Melissa Hanson and Shamaila Waseem and Andrew Singleton and Francis J. McMahon and Maria Anvret and Olof Sydow and Lars Olson},
  journal={Archives of neurology},
  year={2005},
  volume={62 1},
  pages={74-8}
}
BACKGROUND Alcohol dehydrogenases (ADHs) may be involved in the pathogenesis of neurodegenerative disorders because of their multiple roles in detoxification pathways and retinoic acid synthesis. In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample. PATIENTS The previously associated single-nucleotide polymorphism plus 12 further polymorphisms in the ADH cluster on human chromosome 4q23 were screened for association… CONTINUE READING