A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response

@inproceedings{Ikebuchi2016ARS,
  title={A rare subset of skin-tropic regulatory T cells expressing Il10/Gzmb inhibits the cutaneous immune response},
  author={Ryoyo Ikebuchi and Shunsuke Teraguchi and Alexis Vandenbon and Tetsuya Honda and Francis H W Shand and Yasutaka Nakanishi and Takeshi Watanabe and Michio Tomura},
  booktitle={Scientific reports},
  year={2016}
}
Foxp3+ regulatory T cells (Tregs) migrating from the skin to the draining lymph node (dLN) have a strong immunosuppressive effect on the cutaneous immune response. However, the subpopulations responsible for their inhibitory function remain unclear. We investigated single-cell gene expression heterogeneity in Tregs from the dLN of inflamed skin in a contact hypersensitivity model. The immunosuppressive genes Ctla4 and Tgfb1 were expressed in the majority of Tregs. Although Il10-expressing Tregs… CONTINUE READING