A rare case of large cell neuroendocrine carcinoma.

  title={A rare case of large cell neuroendocrine carcinoma.},
  author={Diwei Lin and Amanda Jia Hui Tan and Agnelo Francis De Sousa and Rajinder Singh-Rai},
  journal={BMJ case reports},
We present a very rare case of de novo large cell neuroendocrine carcinoma (LCNEC) of the prostate in an 84-year-old man on a background of high grade, superficially invasive transitional cell carcinoma of the bladder. Pure LCNEC of the prostate is extremely rare. Most LCNEC of the prostate are thought to originate by clonal progression under the selection pressure of therapy and refractory to long-term hormonal treatment for adenocarcinoma of the prostate. De novo LCNEC is only described in… CONTINUE READING