A rapid testing procedure to determine low levels of ocular irritation.

@article{Gupta1976ART,
  title={A rapid testing procedure to determine low levels of ocular irritation.},
  author={Suman Gupta and Diane Schiavo},
  journal={Laboratory animal science},
  year={1976},
  volume={26 3},
  pages={468-72}
}
A new and rapid method for testing low levels of ocular irritation using a balanced incomplete block design, a new grading system, and statistical analysis of the results, has been developed. Two drops (0.1 ml) of 1 of 5 ophthalmic solutions were instilled into the conjunctival sac of the right or left eye of each of 10 New Zealand white [Deb:(NZW)] rabbits hourly for 9 hr on 4 consecutive da. Before the study and before the first instillation on each day, the eyes were examined with a direct… CONTINUE READING

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