A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

@inproceedings{Suleman2013ARS,
  title={A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products},
  author={Sultan Suleman and Kirsten Vandercruyssen and Evelien Wynendaele and Matthias D’hondt and Nathalie Bracke and Luc Duchateau and Christian Burvenich and Kathelijne Y Peremans and Bart De Spiegeleer},
  booktitle={Malaria Journal},
  year={2013}
}
Artemisinin-based fixed dose combination (FDC) products are recommended by World Health Organization (WHO) as a first-line treatment. However, the current artemisinin FDC products, such as β-artemether and lumefantrine, are inherently unstable and require controlled distribution and storage conditions, which are not always available in resource-limited settings. Moreover, quality control is hampered by lack of suitable analytical methods. Thus, there is a need for a rapid and simple, but… CONTINUE READING
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