• Corpus ID: 35905421

A rapid qualitative spot test for the detection of dapsone in urine.

@article{Peters1969ARQ,
  title={A rapid qualitative spot test for the detection of dapsone in urine.},
  author={John H. Peters and S C Lin and Louis Levy},
  journal={International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  year={1969},
  volume={37 1},
  pages={
          46-51
        }
}
  • J. Peters, S. Lin, L. Levy
  • Published 1969
  • Medicine
  • International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
The extensive use of dapsone (4,4'-diaminodiphenyl sulfone, DDS) in the treatment of leprosy, especially in patients for whom unsupervised drug therapy may be employed (a), has led to the need for a simple and accurate method for monitoring drug intake. The availability of such a method would make routine checks on drug intake feasible. We have examined a number of spot test color reagents for detecting DDS in urine directly, but have found none that is sufficiently selective for DDS in the nrf… 

Tables from this paper

A fluorometric method for the simultaneous determination of 4,4'-diaminodiphenyl sulfone (DDS), N-acetyl-DDS (MADDS) and N,N'-diacetyl-DDS (DADDS) in serum or urine.
  • G. Ellard, P. T. Gammon
  • Chemistry
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
  • 1969
TLDR
The method described in this paper has been modified from that originally devised by using sodium citrate and anllydrous sodium sulfate as recommended by Glazko and his co-workers and independently described an extremely sensitive Ruorometric method for the determination of DDS and its acid-hydrolizable derivatives.
Susceptibility of Mycobacterium leprae to Dapsone as a Determinant of Patient Response to Acedapsone
TLDR
Neither acedapsone treatment of patients nor DDS treatment of mice appeared to select genotypically more resistant Mycobacterium leprae, and no relationship could be demonstrated between DDS susceptibility of pretreatment isolates of M. lePrae and the rate at which patients responded to acedAPSone therapy.
The polymorphic acetylation of dapsone in man
The characteristics of the acetylation of dapsone (avlosulfon) were found to parallel those of isoniazid and sulfamethazine in 19 subjects, thereby establishing the genetic polymorphism for the

References

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A new analytical procedure for dapsone. Application to blood-level and urinary-excretion studies in normal men.
TLDR
A new analytical procedure for the assay of DDS was based upon extraction into organic solvents and measurement of fluorescence in anhydrous ethyl acetate, which accounted for 68% of the oral dose and about 54% ofthe intramuscular dose of DADDS.
Applica tion of a spot tes t for detection of DDS in uri ne
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Applica tion of a spot tes t for detection of DDS in uri ne. Leprosy in India
  • 1968
Dapsone assay based on Schiff base fOJID ation
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Dapsone assay based on Schiff base formation.
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  • Biology, Medicine
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
  • 1966