A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).

@article{Lerma1999ARN,
  title={A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).},
  author={J G Garc{\'i}a Lerma and Raymond F Schinazi and Amy S. Juodawlkis and Vicente Soriano and Yulong Lin and Kathleen M Tatti and David Rimland and Thomas M. Folks and Walid Heneine},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 2},
  pages={264-70}
}
Monitoring for lamivudine (3TC) resistance is important both for the clinical management of human immunodeficiency virus type 1 (HIV-1)-infected patients treated with 3TC and for surveillance of transmission of 3TC-resistant HIV-1. We developed a novel non-culture-based assay for the rapid analysis of phenotypic resistance to 3TC of HIV-1 in plasma. The assay measures the susceptibility of HIV-1 reverse transcriptase (RT) activity to 3TC triphosphate (3TC-TP) in plasma. RT detection was done by… CONTINUE READING

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