A rapid method to evaluate potential vasodilatory activity of organic nitrates
@article{Syrtsova2007ARM,
title={A rapid method to evaluate potential vasodilatory activity of organic nitrates},
author={L. Syrtsova and B. Psikha and E. Malkova and N. I. Shkondina and A. Kotelnikov},
journal={Applied Biochemistry and Microbiology},
year={2007},
volume={43},
pages={320-323}
}The kinetics of interaction between organic nitrates (3,3-bis(nitroxymethyl)oxetane) and cysteine were evaluated by the rate of nitrite ion formation at various concentrations of reagents and pH. The activities of natural reducing agents, including cysteine, glutathione, and NADH, in generating the nitrite ion from organic nitrates (3,3-bis(nitroxymethyl)oxetane) were compared. Cysteine was shown to be the most potent reducing agent. Studying the effectiveness of nitrates (trinitroglycerol, 3,3… CONTINUE READING
References
SHOWING 1-10 OF 11 REFERENCES
The reaction between organic nitrates and sulfhydryl compounds. A possible model system for the activation of organic nitrates.
- Chemistry, Medicine
- Molecular pharmacology
- 1985
- 60
Nitrates and NO release: contemporary aspects in biological and medicinal chemistry.
- Chemistry, Medicine
- Free radical biology & medicine
- 2004
- 120
Appearance of Nitrite Reducing Activity of Cytochrome c upon Heat Denaturation
- Chemistry, Medicine
- Bioscience, biotechnology, and biochemistry
- 2002
- 9
Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance.
- Chemistry, Medicine
- Nitric oxide : biology and chemistry
- 2003
- 48
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
- Chemistry, Medicine
- The Journal of clinical investigation
- 2005
- 461
- PDF
Oksid azota (NO). Novyi put' k poisku lekarstv (Nitric Oxide (NO). A New Way to Searching Medicines)
- Moscow: Vuzovskaya kniga,
- 2004