A rapid method to evaluate potential vasodilatory activity of organic nitrates

  title={A rapid method to evaluate potential vasodilatory activity of organic nitrates},
  author={L. Syrtsova and B. Psikha and E. Malkova and N. I. Shkondina and A. Kotelnikov},
  journal={Applied Biochemistry and Microbiology},
  • L. Syrtsova, B. Psikha, +2 authors A. Kotelnikov
  • Published 2007
  • Chemistry, Medicine
  • Applied Biochemistry and Microbiology
  • The kinetics of interaction between organic nitrates (3,3-bis(nitroxymethyl)oxetane) and cysteine were evaluated by the rate of nitrite ion formation at various concentrations of reagents and pH. The activities of natural reducing agents, including cysteine, glutathione, and NADH, in generating the nitrite ion from organic nitrates (3,3-bis(nitroxymethyl)oxetane) were compared. Cysteine was shown to be the most potent reducing agent. Studying the effectiveness of nitrates (trinitroglycerol, 3,3… CONTINUE READING


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