A rapid method for labelling CD4+ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro.

@article{Garden2006ARM,
  title={A rapid method for labelling CD4+ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro.},
  author={Oliver A. Garden and Peter R Reynolds and James W. T. Yates and D. J. Larkman and Federica M. Marelli-Berg and Dorian O. Haskard and Alexander D Edwards and A J T George},
  journal={Journal of immunological methods},
  year={2006},
  volume={314 1-2},
  pages={123-33}
}
A number of techniques have been developed to track the migration of T cells in vivo, but they all suffer significant shortcomings, including the examination of selected organs rather than the organism as a whole--thus precluding longitudinal studies--or limitations imposed by poor spatial resolution and the application of ionizing radiation. By conjugating the HIV tat peptide to ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles in a reaction yielding a mean valence of 45, a… CONTINUE READING

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