• Corpus ID: 34637642

A rapid fluorimetric screening method for the 1,4-benzodiazepines: determination of their metabolite oxazepam in urine.

@article{GilTejedor2007ARF,
  title={A rapid fluorimetric screening method for the 1,4-benzodiazepines: determination of their metabolite oxazepam in urine.},
  author={A M Gil Tejedor and Pilar Fern{\'a}ndez Hernando and J. S. Durand Alegr{\'i}a},
  journal={Analytica chimica acta},
  year={2007},
  volume={591 1},
  pages={
          112-5
        }
}
Oxazepam is the major metabolite screened in urine samples for the evidence of the use of benzodiazepine drugs. The methods currently used, however, are laborious and time consuming. This paper proposes an oxazepam detection method based on its hydrolysis and cyclization--a reaction catalysed by cerium (IV) in an ortho-phosphoric acid-containing medium--to form 2-chloro-9(10H)-acridinone, a strongly fluorescent molecule. The variables involved in the hydrolysis and cyclization stages were… 
Study of On-Line Fluorimetric Determination of Oxazepam. Application to the Screening of 1,4-Benzodiazepines Giving Oxazepam as Metabolite in Urine
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A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
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Three developed techniques for the selective determination of clorazepate dipotassium were described. The three techniques were investigated with dioctyl phthalate (DOP) as a plasticizer in a
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This work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen and obtained recoveries from 93.65 up to 104.96%.
Evaluation of diazepam-molecularly imprinted microspheres for the separation of diazepam and its main metabolite from body fluid samples.
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Water-acetonitrile-acetone mixtures were used as the washing solvent and resulted in complete baseline separation, with a recovery of >87% for diazepam and of 88% for nordiazepam, and the limits of detection are 21.5 and 24.5 ng/mL.