A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids.

@article{Witting1996ARA,
  title={A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids.},
  author={Paul K Witting and C Westerlund and Roland Stocker},
  journal={Journal of lipid research},
  year={1996},
  volume={37 4},
  pages={853-67}
}
We report a rapid and convenient method for screening potential inhibitors of the initiation of low density lipoprotein (LDL) lipid peroxidation. The method uses positively and negatively charged micelles of either cetyltrimethyl ammonium chloride or sodium dodecyl sulfate with added alpha-tocopherol. It is based on the capacity of an antioxidant to attenuate alpha-tocopheroxyl radicals, generated by irradiation of the alpha-tocopherol-containing micelles with UV light, and measured directly by… CONTINUE READING

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