A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.

@article{Toki2018ARA,
  title={A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.},
  author={Hidetoh Toki and Takuya Ichikawa and Akiko Mizuno-Yasuhira and Jun-Ichi Yamaguchi},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2018},
  volume={148},
  pages={
          288-297
        }
}
A novel method for the rapid and sensitive chiral determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid (CSF) was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This method reduces the required matrix volume, compared with a previously reported chiral assay method for ketamine and norketamine… CONTINUE READING