A rapid and reliable method for the quantitation of tricyclic antidepressants in serum using HPLC-MS/MS.

@article{Breaud2009ARA,
  title={A rapid and reliable method for the quantitation of tricyclic antidepressants in serum using HPLC-MS/MS.},
  author={Autumn R Breaud and Robert M. Harlan and Marta Kozak and William Clarke},
  journal={Clinical biochemistry},
  year={2009},
  volume={42 12},
  pages={1300-7}
}
OBJECTIVE Here we describe a liquid chromatography-tandem mass spectrometry method for the detection of tricyclic antidepressant drugs (amitriptyline, desipramine, imipramine, and nortriptyline) in serum. DESIGN AND METHODS Following a protein precipitation from serum and dilution of supernatant with water, these analytes and their internal standards (deuterated versions of each drug) were injected, separated, and eluted from a Hypersil Gold C-18 (50x2.1 mm) analytical column with a gradient… CONTINUE READING
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