A rapid UPLC–MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening

@article{Gucciardi2012ARU,
  title={A rapid UPLC–MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening},
  author={Antonina Gucciardi and Paola Pirillo and Iole Maria Di Gangi and Mauro Naturale and Giuseppe Giordano},
  journal={Analytical and Bioanalytical Chemistry},
  year={2012},
  volume={404},
  pages={741-751}
}
AbstractAcylcarnitine profiling in dried blood spots (DBS) is a useful method for high-throughput newborn screening of metabolic disorders, but differentiation of isobaric and isomeric compounds is not achievable. Chromatographic methods for separation have already been reported but are specific for short-chain acylcarnitines or time-consuming. The aim of this work was to develop a fast ultraperformance liquid chromatography (UPLC)–tandem mass spectrometry (MS/MS) method for separation and… CONTINUE READING

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