A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors.

@article{Papakonstanti2003ARN,
  title={A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors.},
  author={Evangelia A. Papakonstanti and Marilena Kampa and Elias Castanas and Christos Stournaras},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 5},
  pages={
          870-81
        }
}
The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors, which modify the actin cytoskeleton and increase the secretion of prostate-specific antigen (PSA) within minutes. Membrane steroid receptors are, indeed, a newly identified element of steroid action that is different from the classical intracellular sites. In the present work, using a nonpermeable analog of testosterone (testosterone-BSA), we investigated the signaling pathway that is triggered by the… CONTINUE READING
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