A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma.

@article{Lee2011ART,
  title={A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma.},
  author={Anne Wing-Mui Lee and Stewart Yuk Tung and Anthony Tak Cheung Chan and Rick Chappell and Y T Fu and Tai-xiang Lu and Terence Tan and Daniel T T Chua and Brian O'Sullivan and Raymond T Tung and Wai Tong Ng and To-wai Leung and Sing-fai Leung and Stephen S.-T. Yau and Chong Zhao and E. -H. Tan and Gordon K H Au and Lillian L. Siu and Ka-Kit Fung and Wai-hon Lau},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2011},
  volume={98 1},
  pages={15-22}
}
BACKGROUND AND PURPOSE To evaluate the therapeutic benefits by adding chemotherapy (+C) and/or accelerated-fractionation (AF) for patients with T3-4N0-1M0 nasopharyngeal carcinoma. MATERIALS AND METHODS From 1999 to 2004, 189 eligible patients were randomized to one of four treatment groups (CF/CF+C/AF/AF+C). The number of fractions/week was 5 for the CF groups and 6 for the AF groups. Patients in the +C groups were given concurrent cisplatin plus adjuvant cisplatin and fluorouracil… CONTINUE READING