A randomized trial of vonapanitase (PATENCY‐1) to promote radiocephalic fistula patency and use for hemodialysis

  title={A randomized trial of vonapanitase (PATENCY‐1) to promote radiocephalic fistula patency and use for hemodialysis},
  author={A. Bleyer and Vincent A. Scavo and S. Wilson and B. Browne and B. Ferris and K. Ozaki and T. Lee and E. Peden and B. Dixon and R. Mishler and T. O’Connor and K. Kidd and S. Burke},
  journal={Journal of Vascular Surgery},
  • A. Bleyer, Vincent A. Scavo, +10 authors S. Burke
  • Published 2019
  • Medicine
  • Journal of Vascular Surgery
  • Objective Arteriovenous fistulas created in patients with chronic kidney disease often lose patency and fail to become usable. This prospective trial evaluated the efficacy of vonapanitase, a recombinant human elastase, in promoting radiocephalic fistula patency and use for hemodialysis. Methods PATENCY‐1 was a double‐blind, placebo‐controlled trial that enrolled 349 patients on or approaching hemodialysis and being evaluated for radiocephalic arteriovenous fistula creation. Of these, 313 were… CONTINUE READING
    14 Citations
    Molecular targets for improving arteriovenous fistula maturation and patency
    • 4
    Novel Approaches to Arteriovenous Access Creation, Maturation, Suitability, and Durability for Dialysis
    • 3
    Advances in Endovascular Salvage.
    International Comparisons of Native Arteriovenous Fistula Patency and Time to Becoming Catheter-Free: Findings From the Dialysis Outcomes and Practice Patterns Study (DOPPS).


    Arteriovenous fistula patency in the 3 years following vonapanitase and placebo treatment
    • 10
    Human type I pancreatic elastase treatment of arteriovenous fistulas in patients with chronic kidney disease.
    • 40
    Outcomes of arteriovenous fistula creation after the Fistula First Initiative.
    • 138
    • PDF
    Natural History of Upper Limb Arterio-Venous Fistulae for Chronic Hemodialysis
    • 8
    Hemodialysis arteriovenous fistula maturity: US evaluation.
    • 283