A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

@inproceedings{Harris2016ART,
  title={A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma},
  author={Jeffrey M. Harris and Romeo Maciuca and M. Scott Bradley and Christopher R. Cabanski and Heleen Scheerens and Jeremy J Lim and Fang Cai and Mona Kishnani and X. Charlene Liao and Divya Samineni and Rui Zhu and Colette Cochran and Weily Soong and Joseph D. Diaz and Patrick Perin and Miguel Tsukayama and D. Dimov and Ioana Agache and Steven G Kelsen},
  booktitle={Respiratory research},
  year={2016}
}
BACKGROUND Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. In patients with mild asthma, quilizumab reduced serum IgE and attenuated the early and late asthmatic reaction following whole lung allergen challenge. This study evaluated the efficacy and safety of quilizumab in adults with allergic asthma, inadequately controlled despite high-dose inhaled corticosteroids (ICS) and a… CONTINUE READING
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