A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia

@article{Zannolli2012ART,
  title={A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia},
  author={Raffaella Zannolli and Sabrina Buoni and Gianni Betti and Sara Salvucci and Alessandro Plebani and Annarosa Soresina and Maria Cristina Pietrogrande and S. Martino and Vincenzo Leuzzi and Andrea Finocchi and Roberto Micheli and Livia N. Rossi and Alfredo Brusco and Filippo Misiani and Alberto Fois and Joseph Hayek and Colleen Kelly and Luciana Chessa},
  journal={Movement Disorders},
  year={2012},
  volume={27}
}
No controlled studies exist regarding the pharmaceutical reduction of ataxia symptoms in ataxia telangiectasia (A‐T). In a multicenter, double‐blind, randomized, placebo‐controlled crossover trial, oral betamethasone (BETA) and placebo were compared in terms of their reduction of ataxia symptoms as assessed with the International Cooperative Ataxia Rating Scale (ICARS). In this study of 13 A‐T children, betamethasone reduced the ICARS total score by a median of 13 points in the intent‐to‐treat… 
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