A randomized trial of normothermic preservation in liver transplantation

  title={A randomized trial of normothermic preservation in liver transplantation},
  author={David Nasralla and Constantin C Coussios and Hynek Mergental and M Zeeshan Akhtar and Andrew J. Butler and Carlo D. L. Ceresa and Virginia Chiocchia and Susan J Dutton and Juan Carlos Garc{\'i}a-Valdecasas and N. Heaton and Charles J. Imber and Wayel Jassem and Ina Jochmans and John Karani and Simon R Knight and Peri Kocabayoglu and Massimo Mal{\'a}go and Darius Feroze Mirza and Peter J. Morris and Arvind Pallan and Andreas Paul and Mihai Pavel and M Thamara P R Perera and Jacques Pirenne and Reena Ravikumar and Leslie Russell and Sara S Upponi and Christopher J E Watson and Annemarie Weissenbacher and Rutger J Ploeg and Peter John Friend},
Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220… CONTINUE READING