A randomized trial of nicotine enemas for active ulcerative colitis.

  title={A randomized trial of nicotine enemas for active ulcerative colitis.},
  author={John R Ingram and Gareth A. O. Thomas and John Rhodes and John T Green and Neil D Hawkes and Jill L Swift and Emmanuel D Srivastava and Brian K. Evans and Geraint T. Williams and Robert G. Newcombe and Edward Douglas Courtney and Suresh S. K. Pillai},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  volume={3 11},
BACKGROUND & AIMS Ulcerative colitis (UC) is largely a disease of nonsmokers in which transdermal nicotine improves the symptoms but often causes adverse events (AEs). Nicotine enemas cause fewer AEs and were used as supplemental treatment for active UC. METHODS We treated 104 patients with active UC with either 6-mg nicotine enemas or placebo enemas for 6 weeks in a randomized double-blind study. Patients continued their oral therapy, if any, for UC: 68 patients were taking mesalamine, 15… CONTINUE READING
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