A randomized trial of methotrexate versus azathioprine for severe atopic eczema.

@article{Schram2011ART,
  title={A randomized trial of methotrexate versus azathioprine for severe atopic eczema.},
  author={Mandy Elvira Schram and E Roekevisch and Mariska Maria Geertruida Leeflang and Jan Dositheus Bos and Jochen Schmitt and P I Spuls},
  journal={The Journal of allergy and clinical immunology},
  year={2011},
  volume={128 2},
  pages={
          353-9
        }
}
BACKGROUND Patients with severe atopic eczema frequently require systemic treatment to control their disease. Methotrexate and azathioprine are proposed as off-label treatment options, but direct comparisons are lacking. OBJECTIVES We sought to compare the efficacy and safety of methotrexate versus azathioprine in adults with severe atopic eczema. METHODS Patients with severe atopic eczema were randomly assigned in a 1:1 ratio to receive either methotrexate (dosage, 10-22.5 mg/wk) or… CONTINUE READING
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