A randomized trial of intravenous and intracoronary streptokinase in patients with acute myocardial infarction.

@article{Anderson1984ART,
  title={A randomized trial of intravenous and intracoronary streptokinase in patients with acute myocardial infarction.},
  author={Jeffrey L Anderson and Hiram W. Marshall and J C Askins and Jurgen Lutz and Sherman G Sorensen and Ronald L. Menlove and Frank G. Yanowitz and A D Hagan},
  journal={Circulation},
  year={1984},
  volume={70 4},
  pages={606-18}
}
The clinical effects of intravenous streptokinase in patients with acute myocardial infarction were compared with those of intracoronary streptokinase in a randomized, prospective study. Comparisons were also made with a historical control group. Fifty patients were entered into the study at 2.4 +/- 1.2 hr after onset of pain, and 27 were assigned to intravenous and 23 to intracoronary therapy. The doses of streptokinase averaged 212,000 U ic and 845,000 U iv (0.75 X 10(6) U/5 hr, n = 14 or 10… CONTINUE READING

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