A randomized trial of intrahepatic infusion of fluorodeoxyuridine with dexamethasone versus fluorodeoxyuridine alone in the treatment of metastatic colorectal cancer.

@article{Kemeny1992ART,
  title={A randomized trial of intrahepatic infusion of fluorodeoxyuridine with dexamethasone versus fluorodeoxyuridine alone in the treatment of metastatic colorectal cancer.},
  author={Nancy E. Kemeny and Karen Seiter and Donna Niedzwiecki and Douglass Chapman and Elin Ruth Sigurdson and Alan C Cohen and J. C. Pedro Botet and P. Oderman and Peter F. Murray},
  journal={Cancer},
  year={1992},
  volume={69 2},
  pages={
          327-34
        }
}
To decrease the toxicity of hepatic arterial fluorodeoxyuridine (FUDR) administered through an Infusaid pump (Shiley Infusaid, Inc., Norwood, MA), 50 patients with liver metastases from colorectal cancer were selected randomly to receive FUDR, 0.3 mg/kg/d, for 14 of 28 days, with or without a total dose of 20 mg of hepatic arterial dexamethasone for 14 of 28 days. Patients were stratified according to the percentage of liver involvement by tumor and the perfusion pattern on macroaggrated… CONTINUE READING
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