A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer.

@article{Coombes2004ART,
  title={A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer.},
  author={R C Coombes and Emma Hall and Lorna J. Gibson and Robert J. Paridaens and Jacek Jassem and Thierry Delozier and Stephen E. Jones and I Exp{\'o}sito {\'A}lvarez and Gianfilippo Bertelli and Olaf Ortmann and Alan S. Coates and Emilio Bajetta and David Dodwell and Robert Coleman and Lesley Fallowfield and Elizabeth Mickiewicz and Jorn Andersen and Per Eystein L\onning and Giorgio Cocconi and Alan Stewart and Nick Stuart and Claire F Snowdon and Marina Carpentieri and Giorgio Massimini and Judith Margaret Bliss and Cornelius J H van de Velde},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 11},
  pages={1081-92}
}
BACKGROUND Tamoxifen, taken for five years, is the standard adjuvant treatment for postmenopausal women with primary, estrogen-receptor-positive breast cancer. Despite this treatment, however, some patients have a relapse. METHODS We conducted a double-blind, randomized trial to test whether, after two to three years of tamoxifen therapy, switching to exemestane was more effective than continuing tamoxifen therapy for the remainder of the five years of treatment. The primary end point was… CONTINUE READING
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