A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumors.

@article{Bosl1988ART,
  title={A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumors.},
  author={George J. Bosl and Nancy L. Geller and Dean E Bajorin and Silvia Leitner and Alan Yagoda and R. B. Golbey and Howard Scher and Nicholas John Vogelzang and J Todd Auman and Robert T. Carey},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1988},
  volume={6 8},
  pages={1231-8}
}
Standard chemotherapy for disseminated germ cell tumors (GCT) cures most patients but causes considerable acute toxicity, including treatment-related death due to septicemia during neutropenia and pulmonary fibrosis. In addition, chronic and delayed toxicities, particularly Raynaud's phenomenon, have been reported in 6% to 37% of treated patients. In an attempt to minimize the acute and chronic effects of treatment which are related primarily to vinblastine and bleomycin, a randomized trial… CONTINUE READING
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