A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group.

@article{Rolfs1997ART,
  title={A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group.},
  author={Robert T. Rolfs and M Riduan Joesoef and E F Hendershot and Anne Rompalo and Michael H. Augenbraun and M C Chiu and Gail A. Bolan and Samuel Ceaser Johnson and Patrick French and Enno-Edzard Steen and Justin D. Radolf and Steven Larsen},
  journal={The New England journal of medicine},
  year={1997},
  volume={337 5},
  pages={307-14}
}
BACKGROUND Reports of neurosyphilis and invasion of cerebrospinal fluid by Treponema pallidum in patients with human immunodeficiency virus (HIV) infection have led to doubts about the adequacy of the recommended penicillin G benzathine therapy for early syphilis. METHODS In a multicenter, randomized, double-blind trial, we assessed two treatments for early syphilis: 2.4 million units of penicillin G benzathine and that therapy enhanced with a 10-day course of amoxicillin and probenecid. The… CONTINUE READING
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