A randomized trial of botulinum toxin A for treatment of drooling

  title={A randomized trial of botulinum toxin A for treatment of drooling},
  author={Alexandra Lipp and Thomas Trottenberg and Tanja Schink and Andreas Kupsch and G. Arnold},
  pages={1279 - 1281}
The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A; Dysport, Ipsen Pharma, Germany) injections vs vehicle in patients with sialorrhea (n = 32) using a single-center, prospective, double-blind, placebo-controlled dose-finding study. The primary endpoint was achieved with 75 MU BTX-A without treatment-related adverse events, suggesting BTX-A is a safe and effective treatment for patients with sialorrhea. 
Botulinum toxin type A for drooling in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study
BoNTX injections are safe and effective treatment for the management of PD‐related drooling and experienced a reduction in both drooling frequency and familial and social disability. Expand
A Double-Blind Randomized Controlled Trial Investigating the Most Efficacious Dose of Botulinum Toxin-A for Sialorrhea Treatment in Asian Adults with Neurological Diseases
The group receiving 200 U of Dysport® showed the greatest reduction of saliva until 24 weeks and reported the most significant improvement in the DFS score, although no statistically significant difference among the doses was found. Expand
Randomized double‐blind study of botulinum toxin type B for sialorrhea in als patients
Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double‐blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into theExpand
Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparations
  • E. Tan
  • Medicine
  • European journal of neurology
  • 2006
Based on open‐label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian syndromes, motor neuron disease and cerebral palsy. Expand
Parotid Gland Injections of Botulinum Toxin A Are Effective in Treating Sialorrhea in Amyotrophic Lateral Sclerosis
Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea. Expand
Safety and administration of treatment with botulinum neurotoxin for sialorrhoea in ALS patients: Review of the literature and a proposal for tailored treatment
Botulinum neurotoxin treatment for sialorrhoea in ALS patients is safe with few adverse effects, and the authors advocate for the implementation of a personalized treatment strategy. Expand
Botulinum toxin A versus B in sialorrhea: A prospective, randomized, double‐blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson's disease
Either 250 U Dysport or 2500 U Neurobloc have similar effectiveness and safety in controlling sialorrhea and BoNT‐B has a shorter latency and comparable duration. Expand
Disease-oriented approach to botulinum toxin use.
  • J. Jankovic
  • Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 2009
This review will highlight the following therapeutic applications of BoNT in conditions associated with PD: limb dystonia, blepharospasm and lid apraxia, bruxism, cervical dySTONia (anterocollis), camptocormia, hand and jaw tremor, rigidity, freezing of gait, sialorrhea, dysphagia (achalasia), seborrhea, hyperhidrosis, overactive bladder, and constipation. Expand
Treatment of sialorrhea in children with Cerebral Palsy: A double-blind placebo controlled trial
Botulinum toxin is an effective and safe treatment option for drooling in children with CP, and scores of the median frequency and severity of drooling were reduced in the treatment group. Expand
Evidence for the effectiveness of botulinum toxin for sialorrhoea
Recently, botulinum toxin has been introduced as a treatment for sialorrhoea, and in this paper, the evidence for its effectiveness is reviewed. Expand


Efficacy and safety of a standardised 500 unit dose of Dysport® (Clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous cervical dystonia population: results of a prospective, multicentre, randomised, double-blind, placebo-controlled, parallel group study
Although individual dose titration and muscle selection is desirable, this study demonstrated that a dose of 500 units of Dysport injected into clinically identified neck muscles without electromyographic guidance is safe and effective in the treatment of patients with the major clinical types of cervical dystonia. Expand
Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis.
Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea and ameliorated siala and quality of life without major adverse effects. Expand
Botulinum toxin A (BoNT-A) for spasticity in adults. What is the evidence?
The reasons why RCT evidence is being generated are discussed, and the findings currently available are described, including preliminary results from as yet unpublished trials. Expand
Persistent drooling: treatment by bilateral submandibular duct transposition and simultaneous sublingual gland excision.
The procedure was well accepted by the carers, who were also willing to recommend the procedure to others with a similar problem and there was a complete absence of ranula formation in this series. Expand
The Management of Motor Neuron Disease
This book is useful to health care professionals who deal with patients with motor neuron disease, and also to patients who are afflicted with this disorder and their families. Expand
Four-duct ligation: a simple and effective treatment for chronic aspiration from sialorrhea.
  • C. Klem, E. Mair
  • Medicine
  • Archives of otolaryngology--head & neck surgery
  • 1999
This new, simple intraoral procedure controls aspiration pneumonitis with minimal surgical dissection and has less morbidity than procedures involving major salivary gland excision. Expand
The management of motor neurone disease.
  • F. Rose
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 1987
Because of the progressive nature of motor neurone disease (MND), the supportive role of the health care team is of great importance but the physician must play a continuing role, since his attendance demonstrates that there remains much that can be done to help and relieve. Expand
Nonparametric Analysis of Longitudinal Data in Factorial Experiments
  • Subir Ghosh
  • Computer Science, Mathematics
  • Technometrics
  • 2003
Regression and ANOVA is very good in the areas of strength mentioned, and can be a very useful resource for select topics in regression and AnOVA modeling, even though it is not comprehensive enough in either subject to be used as a stand-alone text. Expand