A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.

@article{Yang2003ART,
  title={A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.},
  author={James C Yang and Leah R. Haworth and Richard M. Sherry and Patrick Hwu and Douglas J. Schwartzentruber and Suzanne Louise Topalian and Seth Steinberg and Helen Chen and Steven A Rosenberg},
  journal={The New England journal of medicine},
  year={2003},
  volume={349 5},
  pages={
          427-34
        }
}
BACKGROUND Mutations in the tumor-suppressor gene VHL cause oversecretion of vascular endothelial growth factor by clear-cell renal carcinomas. We conducted a clinical trial to evaluate bevacizumab, a neutralizing antibody against vascular endothelial growth factor, in patients with metastatic renal-cell carcinoma. METHODS A randomized, double-blind, phase 2 trial was conducted comparing placebo with bevacizumab at doses of 3 and 10 mg per kilogram of body weight, given every two weeks; the… CONTINUE READING
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