A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B.

@article{Chahinian1989ART,
  title={A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B.},
  author={A. Phillippe Chahinian and Kathleen Joy Propert and James H. Ware and Basil G. Zimmer and Michael C. Perry and Vera Hirsh and Arthur Skarin and Sheryl Kopel and James F. Holland and Robert L. Comis},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1989},
  volume={7 8},
  pages={993-1002}
}
The Cancer and Leukemia Group B (CALGB) conducted a prospective randomized trial to evaluate the role of warfarin and alternating chemotherapy in extensive small-cell lung cancer (SCCL). After stratification for sex and performance status, patients were randomly assigned to receive chemotherapy with methotrexate, doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH), cyclophosphamide, and lomustine (CCNU) (MACC), or MACC plus warfarin (MACC + W), or mitomycin, etoposide, cisplatin, and… CONTINUE READING