A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.

@article{Strupp2011ART,
  title={A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.},
  author={Michael Strupp and Roger Kalla and Jens Claassen and Christine Adrion and Ulrich Mansmann and Thomas Klopstock and Tobias Freilinger and Hermann Neugebauer and Roland Spiegel and Martin Dichgans and Frank Lehmann-Horn and Karin Jurkat-Rott and Theresa Brandt and Joanna C Jen and Karen Jahn},
  journal={Neurology},
  year={2011},
  volume={77 3},
  pages={269-75}
}
OBJECTIVE The therapeutic effects of 4-aminopyridine (4AP) were investigated in a randomized, double-blind, crossover trial in 10 subjects with familial episodic ataxia with nystagmus. METHODS After randomization, placebo or 4AP (5 mg 3 times daily) was administered for 2 3-month-long treatment periods separated by a 1-month-long washout period. The primary outcome measure was the number of ataxia attacks per month; the secondary outcome measures were the attack duration and patient-reported… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…