A randomized synbiotic trial to prevent sepsis among infants in rural India

@article{Panigrahi2017ARS,
  title={A randomized synbiotic trial to prevent sepsis among infants in rural India},
  author={Pinaki Panigrahi and Sailajanandan N Parida and Nimai C. Nanda and Radhanath Satpathy and Lingaraj Pradhan and Dinesh Singh Chandel and Lorena Baccaglini and Arjit Mohapatra and Subhranshu S. Mohapatra and Pravas R. Misra and Rama Chaudhry and Homer H. Chen and Judith A. Johnson and J. Glenn Morris and Nigel Paneth and Ira H. Gewolb},
  journal={Nature},
  year={2017},
  volume={548},
  pages={407-412}
}
Sepsis in early infancy results in one million annual deaths worldwide, most of them in developing countries. No efficient means of prevention is currently available. Here we report on a randomized, double-blind, placebo-controlled trial of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in rural Indian newborns. We enrolled 4,556 infants that were at least 2,000 g at birth, at least 35 weeks of gestation, and with no signs of sepsis or other morbidity, and… CONTINUE READING
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