A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.

@article{Petersen2003ARS,
  title={A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.},
  author={Karin Lottrup Petersen and Alan Maloney and Frank J Hoke and J\orgen Berg Dahl and Michael C. Rowbotham},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2003},
  volume={4 7},
  pages={400-6}
}
In this randomized double-blind placebo-controlled study, the analgesic effect of oral lamotrigine (400 mg) on cutaneous sensitization induced with the heat/capsaicin sensitization model was compared with the effect of oral hydromorphone (8 mg) in healthy volunteers. In a separate session, intravenous remifentanil (0.10 microg.kg(-1).min(-1)) and placebo were administered. This session was used as an additional reference comparator. Outcome measures were the areas of secondary hyperalgesia to… CONTINUE READING

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