A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial.

@article{Kirkwood1985ARS,
  title={A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial.},
  author={John Munn Kirkwood and Jules E. Harris and R Vera and Stellan Sandler and David S. Fischer and Janardan D. Khandekar and Marc S. Ernstoff and Leo I. Gordon and Richard Lutes and Philip Bonomi},
  journal={Cancer research},
  year={1985},
  volume={45 2},
  pages={
          863-71
        }
}
A prospective randomized trial of low versus high doses of human leukocyte alpha-interferon (1 X 10(6) units/day for 28 days versus 10 X 10(6) units/day for 28 days) was carried out in 30 patients with metastatic renal cell carcinoma, to test the tolerance and relative antitumor effects of these interferon doses. Both doses were tolerated well, and responses to the human leukocyte alpha-interferon were observed overall in seven individuals, including complete, partial, and minimal tumor… CONTINUE READING

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