A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state.

@article{Lissoni1997ARS,
  title={A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state.},
  author={Paolo Lissoni and F. Paolorossi and Antonio Ardizzoia and Sandro Barni and Mario Chilelli and Michelina Mancuso and Gabriele Tancini and Ario Conti and Georges J. M. Maestroni},
  journal={Journal of pineal research},
  year={1997},
  volume={23 1},
  pages={
          15-9
        }
}
Recent studies suggest that the pineal hormone melatonin may reduce chemotherapy-induced immune and bone marrow damage. In addition, melatonin may exert potential oncostatic effects either by stimulating host anticancer immune defenses or by inhibiting tumor growth factor production. On this basis, we have performed a randomized study of chemotherapy alone vs. chemotherapy plus melatonin in advanced non-small cell lung cancer patients (NSCLC) with poor clinical status. The study included 70… CONTINUE READING
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