A randomized study of chemotherapy with procarbazine, vincristine, and lomustine with and without radiation therapy for astrocytoma grades 3 and/or 4.

@article{SandbergWollheim1991ARS,
  title={A randomized study of chemotherapy with procarbazine, vincristine, and lomustine with and without radiation therapy for astrocytoma grades 3 and/or 4.},
  author={Magnhild Sandberg-Wollheim and P Malmstr{\"o}m and Lars G{\"o}ran Str{\"o}mblad and Heather Anderson and S G Borgstr{\"o}m and Arne Brun and S E Cronqvist and Kjeld Hougaard and Leif G. Salford},
  journal={Cancer},
  year={1991},
  volume={68 1},
  pages={22-9}
}
The authors undertook a controlled, prospective, randomized study of 171 patients with supratentorial astrocytoma grades 3 and/or 4 (classified according to Kernohan). All patients were given chemotherapy consisting of procarbazine, vincristine, and lomustine (CCNU) (PVC). Half of the patients received whole-brain irradiation (RT) to a dose of 5800 cGy in the tumor-bearing hemisphere and 5000 cGy in the contralateral hemisphere. After diagnosis of progressive tumor growth, patients received… CONTINUE READING

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